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Creatinine clearance (CrCl) estimated by the Cockcroft-Gault equation is used for drug dosing (especially renally-cleared medications), whereas eGFR is used for CKD staging. They give similar but not identical values.

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1. 1CrCl = [(140−Age) × Weight(kg)] / (72 × Serum creatinine mg/dL)
2. 2Multiply by 0.85 for females
3. 3Uses actual body weight; in obesity, use ideal body weight or adjusted body weight
4. 4Important for dosing: aminoglycosides, vancomycin, metformin, direct oral anticoagulants

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