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Corrigan dosage calculates digoxin loading dose based on body weight and renal function. It's critical for preventing toxicity.
Formel
Calculate: Loading dose = (weight × 10-15 mcg/kg) adjusted for renal clearance
Trin-for-trin guide
- 1Calculate: Loading dose = (weight × 10-15 mcg/kg) adjusted for renal clearance
- 2Reduce dose 20-25% for each decade over age 40
- 3Maintenance: (CrCl/5) + 0.01 × weight in mcg daily
Løste eksempler
Input
70 kg, age 75, CrCl 45 mL/min
Resultat
Loading 500-750 mcg, maintenance 0.125-0.25 mg daily
Adjusted for age and renal function
Almindelige fejl at undgå
- ✕Not measuring baseline renal function before dosing
- ✕Forgetting electrolyte abnormalities (low K, Mg increase risk)
Ofte stillede spørgsmål
Why adjust for age and renal function?
Elderly and renal-impaired patients have reduced digoxin clearance, increasing toxicity risk.
What signs indicate toxicity?
Arrhythmias, nausea, visual disturbances, confusion. Therapeutic level 0.8-2.0 ng/mL; above becomes toxic.
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