🧬Selection Coefficient Calculator
The selection coefficient (s) quantifies the fitness disadvantage of a genotype. If the fittest genotype has relative fitness 1, a genotype with fitness (1−s) has selection coefficient s.
- 1s = 1 − w_aa/w_AA
- 2Allele frequency change: Δq ≈ −sq²p/(1−sq²)
w_AA=1.0 · w_aa=0.7=s = 0.3 (30% fitness reduction)Moderate selection against recessive
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Fun Fact
Sickle cell anemia shows balanced selection: s≈1 for homozygous recessive but carriers have positive selection in malaria-endemic regions.
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