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The GLP-1 Cardiovascular Benefit Calculator estimates the reduction in major adverse cardiovascular events (MACE) risk based on data from the landmark SELECT trial of semaglutide 2.4 mg. It calculates your personalized MACE risk reduction based on age, cardiovascular history, and GLP-1 treatment duration.

공식

Reduced MACE Risk = Baseline MACE Risk × (1 - Hazard Ratio Reduction)

MACE₀: Baseline MACE Risk (%/year) — Annual risk of major adverse cardiovascular events without GLP-1 therapy
HR: Hazard Ratio (ratio) — Relative risk from SELECT trial (0.80 = 20% relative reduction)
ARR: Absolute Risk Reduction (%/year) — Annual absolute decrease in MACE risk
NNT: Number Needed to Treat (patients) — Number of patients treated to prevent one MACE event

단계별 가이드

1Enter your age, cardiovascular risk factors, and history of heart attack or stroke
2Select your GLP-1 medication and dose
3The calculator estimates your baseline annual MACE risk and the expected reduction from GLP-1 therapy
4View the number needed to treat (NNT) and absolute risk reduction for your profile

풀어진 예시

입력

Age 60, history of MI, BMI 34, on semaglutide 2.4 mg

결과

Baseline annual MACE risk: ~4.5%. With semaglutide (HR 0.80 from SELECT): reduced to ~3.6%. Absolute risk reduction: 0.9%/year. NNT over 3.3 years: ~15.

입력

Age 50, no prior CV events, overweight with hypertension

결과

Baseline annual MACE risk: ~1.5%. With semaglutide: reduced to ~1.2%. Absolute risk reduction: 0.3%/year. NNT much higher — benefit is proportional to baseline risk.

피해야 할 일반적인 실수

✕Applying SELECT trial results to patients without established cardiovascular disease — the trial enrolled patients with prior CV events or high CV risk
✕Confusing relative risk reduction (20%) with absolute risk reduction (which depends on baseline risk)
✕Assuming all GLP-1 medications have proven cardiovascular benefit — only semaglutide has completed a CV outcomes trial in obesity

자주 묻는 질문

Does Ozempic or Wegovy reduce heart attack risk?

Yes. The SELECT trial (2023) demonstrated that semaglutide 2.4 mg reduced MACE (heart attack, stroke, cardiovascular death) by 20% compared to placebo in overweight/obese adults with prior cardiovascular disease. This was the first obesity medication to show a direct cardiovascular benefit.

Do I need to have had a heart attack to benefit from the cardiovascular protection?

The SELECT trial enrolled patients with established cardiovascular disease (prior heart attack, stroke, or peripheral artery disease) plus BMI ≥ 27. While the cardiovascular benefit is proven in this population, trials in lower-risk populations are ongoing.

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