GFR Calculator (CKD-EPI 2021)
The estimated Glomerular Filtration Rate (eGFR) measures how well the kidneys filter waste from the blood. It is calculated from serum creatinine, age, and sex using the CKD-EPI 2021 equation (race-free version). eGFR is the primary metric for diagnosing and staging Chronic Kidney Disease (CKD).
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Tip: eGFR naturally declines with age — approximately 1 mL/min/year after age 40. An eGFR of 60 in a 75-year-old may be less concerning than the same reading in a 40-year-old. Always interpret with clinical context.
- 1CKD-EPI 2021: eGFR = 142 × min(Scr/κ, 1)^α × max(Scr/κ, 1)^(−1.200) × 0.9938^Age × (1.012 if female)
- 2κ = 0.7 (female) or 0.9 (male); α = −0.241 (female) or −0.302 (male)
- 3Units: mL/min/1.73m² (normalised to average body surface area)
- 4A single eGFR < 60 for 3+ months defines CKD
Female, 55yo, creatinine 1.0 mg/dL=eGFR ≈ 66 mL/min/1.73m² (G2)Mildly decreased — monitor
Male, 70yo, creatinine 2.0 mg/dL=eGFR ≈ 32 mL/min/1.73m² (G3b)Moderate-severe decrease
| Stage | eGFR Range | Description |
|---|---|---|
| G1 | ≥ 90 | Normal or high — kidney damage markers may be present |
| G2 | 60–89 | Mildly decreased |
| G3a | 45–59 | Mildly to moderately decreased |
| G3b | 30–44 | Moderately to severely decreased |
| G4 | 15–29 | Severely decreased |
| G5 | < 15 | Kidney failure — dialysis or transplant needed |
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