How does the Henderson-Hasselbalch work?

Identify the weak acid (HA) and its conjugate base (A⁻) Then: Find or calculate pKa = −log(Ka) Then: Measure concentrations [HA] and [A⁻] Then: pH = pKa + log([A⁻]/[HA]).

Can you give an example of how to use the Henderson-Hasselbalch?

Example: Input Acetic acid pKa=4.76 · [CH₃COO⁻]=0.1M · [CH₃COOH]=0.1M gives a result of pH = 4.76 (Equal concentrations → log(1)=0 → pH=pKa).

Is the Henderson-Hasselbalch free to use?

Yes — completely free with no registration, download, or subscription required. All calculations happen instantly in your browser.

How accurate is the Henderson-Hasselbalch?

Our Henderson-Hasselbalch uses verified mathematical formulas and is accurate to multiple decimal places. Results are calculated in real-time using the same methods used by professionals.

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Henderson-Hasselbalch

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pKa

[A⁻] base (mol/L)

[HA] acid (mol/L)

The Henderson-Hasselbalch equation calculates the pH of a buffer solution containing a weak acid and its conjugate base. pH = pKa + log([A⁻]/[HA]). It is fundamental in biochemistry for maintaining physiological pH.

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Did You Know?

Blood is a bicarbonate buffer system (pKa 6.1) maintained at pH 7.4. Deviations of ±0.4 units cause acidosis or alkalosis — life-threatening conditions.

References

›Henderson-Hasselbalch equation — Wikipedia

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Henderson-Hasselbalch

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