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Selection Coefficient

Natural selection coefficient s

🧬Selection Coefficient Calculator

The selection coefficient (s) quantifies the fitness disadvantage of a genotype. If the fittest genotype has relative fitness 1, a genotype with fitness (1−s) has selection coefficient s.

Fun Fact

Sickle cell anemia shows balanced selection: s≈1 for homozygous recessive but carriers have positive selection in malaria-endemic regions.

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