Creatinine clearance (CrCl) estimated by the Cockcroft-Gault equation is used for drug dosing (especially renally-cleared medications), whereas eGFR is used for CKD staging. They give similar but not identical values.
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Did You Know?
Cockcroft-Gault (1976) was derived from 249 patients — a tiny sample by modern standards. Yet it remains the standard for drug dosing 50 years later because it has been extensively validated.
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